> CLINICAL RESULTS
Cicabio SPF50+ demonstrates an immediate soothing effect during stinging test: -80%* stinging intensity after 30 sec. (1)
With a multi-centric clinical evaluation on skin lesions,
Cicabio SPF50+ demonstrates a significant decrease of redness (-79%**) with significant soothing effect after 14 days. (2)
Cicabio SPF50+ significantly increases skin hydration after a single application: +30,8% after 2h, +11,4% after 8h ***, compared to untreated zone. (3)
With an in vivo model of post-inflammatory hyperpigmentation created by stripping and UV + visible light exposure *(4):
- The alterations of the stratum corneum were significantly reduced with Cicabio SPF50+ (assessed by TEWL(a) measure) during the first 6 days, demonstrating repairing effect
- The pigmentation was significantly lower up to the end of the study (28 days) with Cicabio SPF50+
- Cicabio SPF50+ maintained skin lightness, limited skin redness and skin yellowness.
TOLERANCE
Cicabio SPF50+ was very well tolerated by sensitive damaged skin, with very good ocular tolerance. (5)
Cicabio SPF50+ was very well tolerated on infants’ irritated skin. (6)
(a) Trans Epidermal Water Loss. The lower it is, the more water is retained in the skin and therefore the skin's barrier function is good
> PATIENTS FEEDBACKS
The product is pleasant to use for 100%. (7)
* p<0.05, T-test or Wilcoxon test, compared to untreated zone.
** p<0.001, Shapiro-Wilk test compared with D0
*** p<0.05, Student T-test
(1)Stinging test on 21 female subjects aged from 18 to 54 years old with dry to greasy skin, with a unique application of Cicabio SFP50+ after capsaicin application on nasolabial skin. Scoring of stinging intensity 30 sec, 3 min, 6 min and 9 min. Poland. 2019.
(2)Clinical study on 1104 subjects aged from 18 to 93 years old who received a prescription from 298 dermatologists of Cicabio SPF50+ application during 14 days on superficial, non-oozing skin lesions at risk of scaring and/or pigmentation marks. Evaluation of redness by the investigator and of subjective signs scored by subjects (heat sensation, pain, itching, feeling of discomfort/tightness). France. 2016.
(3)In vivo evaluation of skin hydration, assessed by corneometer, after a single application of Cicabio SFP50+ on the inner forearm (compared to untreated zone), 10 female volunteers aged from 36 to 70 years old dry or moderately hydrated skin. France. 2018.
(4)Clinical study on 30 subjects aged from 19 to 49 years old of repairing and post-inflammatory hyperpigmentation protection efficacies of Cicabio SPF50+. Skin was previously stripped, then product applied once, followed by UV and visible light exposure. Cicabio SPF50+ was then applied once daily for 7 days. TEWL, erythema clinical score, pigmentation score and colorimetric parameters (L*a*b*) were analyzed from D0 to D7, and at D28. France. 2019.
(5)Use test on 20 volunteers aged from 24 to 68 years old with sensitive skin and sun exposed damaged skin zones (scars, closed wounds, minor to moderate burns; on face body or lips), after 21 days of application of Cicabio SPF50+ at least once daily. France. 2018.
(6)Use test under pediatric control on 22 subjects aged from 7 to 35 months old with dry skin and sun exposed irritated zones, after 21 days of application of Cicabio SPF50+ at least twice daily. Mauritius. 2012
(7)Clinical study on 30 subjects aged from 42 to 70 years old with all types of skin having received a face skin dermabrasion by an aesthetic laser treatment, after 3 days of twice daily application of Cicabio SPF50+. Satisfaction questionnaire filled by the subjects. France. 2018.
