> CLINICAL RESULTS
Cicabio Lotion Spray demonstrates significant drying power by reducing the skin hydration: -30% 4 hours after a single application, and even -20% after 8 hours. *(1)
* p<0,01, Student T-test.
The Cicabio active ingredients mimic and stimulate the biological processes of each of the natural stages of healing thanks to its complex of repairing active ingredients: Resveratrol, Copper Sulfate, Centella Asiatica.
A study conducted in vitro on human keratinocyte culture showed that an extract rich in Resveratrol stimulates the secretion of growth factor (VEGF).(2) Furthermore, according to the in vivo study on wounded mice, topical application of a Resveratrol-rich extract accelerates contraction - closure of the wound and improves healing.(3)
Copper sulfate stimulates the secretion of growth factor (+36% vs control), has antiseptic properties and accelerates the dermal contraction of the wound in mice.(4)
Centella asiatica improves the wound healing process by stimulating the production of type I collagen and elastin in the injured and treated area, as demonstrated by an in vitro study carried out on human fibroblasts.(5)
CHICKENPOX SYMPTOMS
After 7 days of Cicabio Lotion Spray application, itching sensations were significantly decreased (-76%).*(6)
After 14 days of Cicabio Lotion Spray application, symptoms of varicella were significantly reduced: macules (-100%), papules (-92%), blisters (-100%) and itching (-98%). *(6)
* p<0,0001.
UMBILICAL CORD
After twice daily application of Cicabio Lotion Spray, an average time of 5,2 days for cord separation was reported.
After 10 days of Cicabio Lotion Spray, application, the drying effect was considered good to very good by 96,0% of pediatricians, for 100% the product has purifying effect and for 100% it promoted umbilical cord separation and wound healing.
A total disappearance of clinical signs was assessed after 30 days, such as erythema, oedema, oozing, bleeding, and granulation tissue.(7)
NAPPY RASH
After 7 and 14 days of Cicabio Lotion Spray application, the erythema was significantly decreased (-47% at D7, -85% at D14*), and the itching was abolished (-100% at D7 and D14). (8)
*p<0,001, Wilcoxon test.
TOLERANCE
Cicabio Lotion Spray on chickenpox in children was considered as very well-tolerated for 96.7% of subjects and well-tolerated for 3.3% of them. (6)
Cicabio Lotion Spray on umbilical cord of newborns, the product tolerance was found to be good to very good by the pediatricians. For all parents, the product was well tolerated by the baby, and it did not irritate the skin. (7)
> PATIENTS FEEDBACKS
The product’s texture is pleasant for 96% of newborns’ parents. (7)
The spray ensures easy application to the umbilical cord for 100% of newborns’ parents. (7)
It soothes between each diaper change for 100% of subject’s parents. (8)
It spreads without leaving a white mark for 80% of subjects’ parents. (8)
It soothes immediately the skin for 75% of subjects. (9)
It soothes durably the skin for 90% of subjects. (9)
(1)In vivo evaluation of reduction in skin hydration, assessed by corneometer, after applying Cicabio Lotion Spray – 10 female volunteers aged from 37 to 68 years old with hydrated skin. France. 2018.
(2)Khanna S. et al. Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract. Free Radic Biol Med. 2001; 31 (1): 38-42.
(3)Khanna S. et al. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med. 2002; 33 (8): 1089- 96.
(4)Sen CK. Et al. Copper-induced vascular endothelial growth factor expression and wound healing. Am J Physiol Heart Circ Physiol. 2002; 282: 1821-27
(5)Lee J. et al. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signalling. Planta Med. 2006; 72 (4): 324-8
(6)Clinical study on 30 subjects aged from 3 to 10 years old presenting chickenpox, after 14 days of Cicabio Lotion spray application twice daily. Macules, papules and blisters were counted on a defined area. Itching sensations were evaluated using the Visual analogic Scale. Georgia. 2019
(7)Clinical study on 25 newborns, after 10 to 30 days of Cicabio Lotion spray application twice daily on the umbilical cord from birth. Scoring of clinical signs pediatricians. Efficacy and satisfactory questionnaires were filled on D10 and D30 by pediatricians and newborn’s parents. Spain. 2019.
(8)Clinical study on 30 subjects aged from 4 to 35 months with erythema on the diaper area, after 28 days of Cicabio Lotion spray application twice daily. Scoring of clinical signs (erythema), functional signs (itching) by pediatricians. Efficacy and satisfactory questionnaires were filled on D28 by subject’s parents. Poland. 2022.
(9)Use test on 20 subjects aged from 24 to 56 years old with sensitive and normal to very dry skin, after 7 days of Cicabio Lotion Spray application once daily on the leg.
