> CLINICAL RESULTS
After 28 days of application, twice daily, the results showed a significant reduction -19% * in trans-epidermal water loss (TEWL) compared to T0. Thus, demonstrating that Hydrabio Gel Creme has an effect on the restructuring of the skin barrier. (2)
Hydrabio Gel crème has an excellent moisturizing power as it increases skin hydration rate by +38.6%* at 2 hours after only one application, and +34.1%* at 8 hours. (3)
The AquageniumTM patented complex helps the skin to reconstitute its own resources and restore its original hydrating abilities. This complex contains active ingredients that: (1)
- improve the hydric flows by stimulating Aquaporin-3 synthesis thanks to Pyrus Malus fruit extract. An in vitro study was conducted on keratinocytes. After addition of Pyrus Malus fruit extract, an RT-PCR analysis showed an increase in ARMm synthesis coding for Aquaporin-3. (+55% synthesis vs control)
- restore the lipids that bond the corneocytes and thus improve the horny layer’s impermeability.
Hydrabio Gel Crème contains salicylic acid. A study showed that salicylic acid makes the skin brighter and reflects lighter (+0.88% vs. 0.03%) *. Moreover, the skin texture was finer and more even (respectively -3.18% vs -0.66% and -0.42% vs -0.04%) after exposition to salicylic acid compared to the control. The presence of salicylic acid has a positive effect on the skin. (4)
TOLERANCE
Hydrabio Gel crème is very well tolerated on the ocular level and on the cutaneous level, no reaction of skin or eyes were observed. (5,6)
* p< 0.05, Student’s Test, after 28 days or after 8 hours.
> PATIENTS FEEDBACKS
After 7 days of using Hydrabio Gel Creme, twice daily:
- 86.8% of volunteers reported the skin was comfortable. (5)
- More than 70% of them reported that they had the feeling that skin was hydrated, and fine lines induced by dehydration were smoothed (4)
- Lastly, 80% of them found the product was melting, had a pleasant touch and was easy to spread. (5)
(1)In vitro test on keratinocytes – evaluation of Aquaporine-3 synthesis by Pyrus Malus fruit extract (0.1%) - RT-PCR analysis
(2)In vivo evaluation of the trans-epidermal water loss (TEWL) of Hydrabio Gel Crème – 10 volunteers (aged 20-42 years old) with dry skin on the legs. France 2014
(3)In vivo evaluation of hydration power of Hydrabio Gel Crème, double blind trial – 10 volunteers (aged 34 – 64 years old) with dry or moderately hydrated skin on the forearms. France 2014
(4)Evaluation of the effect of salicylic acid (0.2%) on skin radiance versus a placebo – 38 volunteers (aged 33 – 61 years old) with normal facial skin. France. 2014
(5)User test performed on Hydrabio Gel Crème with mixed and dehydrated skin on the face - 22 volunteers (aged 25 to 35 years old) with dehydrated and sensitive combination skin on the face. Japan. 2014
(6)User test on Hydrabio Gel crème with dry facial skin – 20 volunteers (aged 19-46 years old) with dry facial skin. France. 2014