Cutaneous detoxification: the central role of Nrf2 in the skin's adaptation to environmental stresses

Summary of publications on the role of Nrf2 in skin detoxification by the scientific teams at Laboratoire Dermatologique Bioderma.

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By regulating the synthesis of antioxidant proteins and detoxification enzymes, the transcription factor Nrf2 represents an essential intrinsic protective mechanism for maintaining skin homeostasis against daily environmental aggressions.
Prolonged or repeated exposure to sunlight and pollution can overwhelm endogenous detoxification capacities, increasing the risk of irreversible cellular damage.
Activating the Nrf2 transcriptional pathway offers a promising target for enhancing the skin's physiological defense mechanisms against sunlight and pollution.

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