Pure Active D-Panthenol 5%

• 5% is the right dose according to 2 independent clinical studies published in scientific literature ^{(1) (2)} which showed a significant skin barrier repair, increase in stratum corneum hydration and acceleration of epidermal regeneration.
• IN-SKIN patented technology: diffusion booster to deliver the active ingredient exactly where it needs to go, with a X3 improvement of diffusion into the skin ^(3).
• Quick penetration and non-oily⁽⁴⁾ Very well-tolerated ⁽⁵⁾

1. Proksch E, Nissen HP. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. J Dermatolog Treat. 2002;13(4):173-178. doi:10.1080/09546630212345674
2. Ebner F, Heller A, Rippke F, Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol. 2002;3(6):427-433. doi:10.2165/00128071-200203060-00005Ex-vivo tests on Franz cells: comparison between the diffusion of a standard formula, containing IN-SKIN™ plus 2% caffeine (ingredient selected as example), and the diffusion of a standard formula containing only 2% caffeine (without IN-SKIN™)
3. Use test, 30 volunteers aged from 21 to 50 years old, with very dry skin on the face, hands & feet. Twice-daily application on the face, hands & feet, 28 days. Self-assessment. 
4. Tolerance assessment under dermatological control, 30 volunteers aged from 21 to 50 years old, after 28 days of use.  

> CLINICAL RESULTS

Independent study published by Camargo et al.: -35%*** in TEWL after 30 days. ⁽¹⁾

> PATIENTS FEEDBACK

Immediately:

• skin is more comfortable (for 97% of subjects) ⁽²⁾.

After 28 days of twice daily application: 

• skin is more nourished (for 90% of subjects) ⁽²⁾
• skin is more radiant (for 94% of them) ⁽²⁾
• skin is less dry and roughness is reduced (for 90% of them) ⁽²⁾

***p<0.001, ANOVA test

1. Clinical study conducted on 40 women aged 20 to 35, for 30 days. Camargo FB Jr, Gaspar LR, Maia Campos PM. Skin moisturizing effects of panthenol-based formulations. J Cosmet Sci. 2011;62(4):361-370.
2. Use test, 30 volunteers aged from 21 to 50 years old, with very dry skin on the face, hands & feet. Twice-daily application on the face, hands & feet, 28 days. Self-assessment.