Pure Active Glabridin 250ppm

• A lightening effect, especially on spot area. Complexion is more homogeneous ⁽¹⁾.
• Reduces dark spot intensity: -9.7%* after 56 days ⁽²⁾
• IN-SKIN patented technology: diffusion booster to deliver the active ingredient exactly where it needs to go, with a X3 improvement of Pure Active diffusion into the skin ^(3).
• Suitable for sensitive skin ⁽¹⁾ Well tolerated ^(4).
• Quick penetration and non-oily ⁽⁵⁾
  

*p<0.05, t-test

1. Clinical test under dermatological control, 32 volunteers, 35 to 65 years old, 100% sensitive skin, all skin types with pigment spots/having hyperpigmented skin on the face + having post inflammatory spots. Twice-daily application on the face, neck and neckline, 56 days. Spectrophotometry.
2. Clinical test under dermatological control, 32 volunteers, 35 to 65 years old, 100% sensitive skin, all skin types with pigment spots/having hyperpigmented skin on the face + having post inflammatory spots. Twice-daily application on the face, neck and neckline, 56 days. Clinical scoring. 
3. Ex-vivo tests on Franz cells: comparison between the diffusion of a standard formula, containing IN-SKIN™ plus 2% caffeine (ingredient selected as example), and the diffusion of a standard formula containing only 2% caffeine (without IN-SKIN™)
4. Clinical assessment of the tolerance, 20 volunteers, 35 to 65 years old, all skin types. Twice a day for 14 to 16 days.
5.  Clinical test under dermatological control, 32 volunteers, 35 to 65 years old, 100% sensitive skin, all skin types with pigment spots/having hyperpigmented skin on the face + having post inflammatory spots. Twice-daily application on the face, neck and neckline, 56 days. Self-assessment.

> CLINICAL RESULTS

After 56 days of twice-daily application:

• Reduces the intensity of brown spots : -9,7%*⁽¹⁾.
• Promotes even skin tone : +24,1%* ⁽²⁾.
• Reduction of dark spot intensity: +29.6%* in ITA° (individual typological angle) in spot area, and +4.4%* on non-spot area. ⁽²⁾

> PATIENTS FEEDBACKS

After 56 days of twice daily application: 

• skin is more radiant (for 96% of subjects) ⁽³⁾
• skin is more even (for 93% of them) ⁽³⁾
• intensity of dark spots is reduced (for 90% of them) ⁽³⁾

*p<0.05, t-test

1. Clinical test under dermatological control, 32 volunteers, 35 to 65 years old, 100% sensitive skin, all skin types with pigment spots/having hyperpigmented skin on the face + having post inflammatory spots. Twice-daily application on the face, neck and neckline, 56 days. Clinical scoring.
2. Clinical test under dermatological control, 32 volunteers, 35 to 65 years old, 100% sensitive skin, all skin types with pigment spots/having hyperpigmented skin on the face + having post inflammatory spots. Twice-daily application on the face, neck and neckline, 56 days. Spectrophotometry. 
3. Clinical test under dermatological control, 32 volunteers, 35 to 65 years old, 100% sensitive skin, all skin types with pigment spots/having hyperpigmented skin on the face + having post inflammatory spots. Twice-daily application on the face, neck and neckline, 56 days. Self-assessment.