Pure Active Hyaluronic Acid 1,5%

• Wrinkles filler: -18%*** of crow’s feet wrinkles* and -16%*** of forehead wrinkles. ⁽¹⁾
• Hydration: skin is intensely moisturized (reported by 87% of volunteers). ⁽²⁾
• IN-SKIN patented technology: diffusion booster to deliver the active ingredient exactly where it needs to go, with a X3 improvement of Pure Active diffusion into the skin ^(3).
• Combines high molecular weight hyaluronic acid (between 600 and 2000 kDa) and low molecular weight hyaluronic acid (< 50kDa).
• Suitable for sensitive skin ⁽¹⁾ – Very well tolerated ⁽²⁾ - Pleasant and fresh texture ⁽²⁾ – Quick penetration ⁽²⁾.

***p<0.0001, Wilcoxon test.

1. Use test under dermatological control, 30 volunteers aged from 42 to 60 years old, 100% sensitive skin, all skin type, with wrinkles on forehead and crow’s feet. 28 days. Clinical scoring. 2021
2. Use test under dermatological control, 33 volunteers aged from 41 to 60 years old, sensitive skin, all skin type, with wrinkles and fine lines on the crow’s feet. 28 days. Self-assessment. 2020
3. Ex-vivo tests on Franz cells: comparison between the diffusion of a standard formula, containing IN-SKIN™ plus 2% caffeine (ingredient selected as example), and the diffusion of a standard formula containing only 2% caffeine (without IN-SKIN™)

> CLINICAL RESULTS

After 28 days of twice-daily use, significant reduction in scores for crow’s feet wrinkles (-18%***) and forehead wrinkles (-16%***). ⁽¹⁾

After 28 days of once-daily use, significant decrease of 10%* in the Uf parameter (final deformation): skin is firmer ⁽²⁾.

After 28 days of once-daily use ⁽³⁾: +23%*** in tonicity and suppleness

• +19% of softness***
• +11 of firmness***
• +10% of elasticity**
• +9% of density **
• -6%** in subocular fine lines score

> PATIENTS FEEDBACKS

Immediately:

-  skin is replumped (for 91% of subjects) ⁽⁴⁾.

- Hyaluronic Acid 1.5% gives tensor effect (mentioned by 88% of subjects) ⁽⁴⁾.

After 28 days of twice daily application: 

• skin regains suppleness & tonicity (for 94% of subjects) ⁽⁴⁾
• skin is firmer and repulped skin (for 91% of them) ⁽⁴⁾
• wrinkles and fine lines are reduced (for 91% of them) ⁽⁴⁾
• skin is redensified (for 88% of them) ⁽⁴⁾
• skin is intensely moisturized (for 87% of them) ⁽⁴⁾

***p<0.001, Wilcoxon.

**p<0.01, Wilcoxon.

*p<0.05, t-test.

1. Use test under dermatological control, 30 volunteers aged from 42 to 60 years old, 100% sensitive skin, all skin type, with wrinkles on forehead and crow’s feet. 28 days. Clinical scoring. 2021 
2. Use test under dermatological control, 22 volunteers aged from 39 to 59 years old, with wrinkles, fine lines, and a loss of firmness. 28 days. Measure with Cutometer. 2019
3. Use test under dermatological control, 22 volunteers aged from 39 to 59 years old, with wrinkles, fine lines, and a loss of firmness. 28 days. Clinical scoring. 2019
4. Use test under dermatological control, 33 volunteers aged from 41 to 60 years old, sensitive skin, all skin type, with wrinkles and fine lines on the crow’s feet. 28 days. Self-assessment. 2020