4 professionals
Interest of a dermo-cosmetic product in the management of irritant and allergic contact eyelid dermatitis
Interest of a dermo-cosmetic product in the management of irritant and allergic contact eyelid dermatitis
Floriane Gayraud1, Nathalie Ardiet1, Marlène Chavagnac-Bonneville1,2, Christelle Graizeau1,2 and Michèle Sayag1
1NAOS Group, Research and Development Department, Lyon, France
2NAOS Institute of Life Science, Aix-en-Provence, France
Related topics
Eyelid inflammation is mainly due to irritant and allergic contact dermatitis (IACD) (50 to 76%). They are mostly characterized by dryness, erythema, edema and itching, that could impact their quality of life.
The aim is to evaluate the repairing and soothing effects, the impact on quality of life and the safety of this product on IACD.
Firstly, to evaluate the anti-redness effect, skin colour was measured on 22 healthy subjects using a spectrophotometer before/after application of patches containing the product with 1% SLS. Secondly, an observational study was performed including 45 subjects affected by IACD. They applied the product for 28 days twice daily. At Day 0 and D28, the clinical repairing and soothing assessment were performed by the dermatologist using an 11-point scale. During the study, the subjects evaluated the subjective efficacy by using a four-point scale, and their quality of life by using the SKINDEX-16 questionnaire. The investigator also evaluated the tolerance.
Redness was reduced by 47% (p<0.001) with the product via the colorimetric parameter a*. In the clinical study, 44 subjects with a majority of ICD (86.4%) were included. At D28, the dermatologist evaluated a decrease (p<0.01 to p<0.0001) for roughness -95.5%, desquamation -100%, erythema -93.3%, edema -100%, stinging -88.0%, tightness -100%, itching -89.3% , burning sensation -100% and discomfort -92.9%. Moreover, more than 80% of subjects agreed that the product lastingly repaired and moisturized the skin and was suitable for caring and cleansing irritated eyelids. Their quality of life was improved at D28: -57.7% of SKINDEX-16 total score (p<0.001), including -77.5% for the symptoms. The product was well tolerated.
This study demonstrated that this dermo-cosmetic product efficiently soothes, repairs and cleanses the eyelid skin of IACD subjects and is relevant in the management of this pathology.
Christelle Graizeau, Research director of NAOS
Floriane Gayraud1, Nathalie Ardiet1, Marlène Chavagnac-Bonneville1,2, Christelle Graizeau1,2 and Michèle Sayag1
1NAOS Group, Research and Development Department, Lyon, France
2NAOS Institute of Life Science, Aix-en-Provence, France
Gayraud(1), N. Ardiet(1), M. Chavagnac-Bonneville(1,2), M. Sayag(1)
(1)NAOS Group, Research and Development Department, Aix-en-Provence, France
(2)NAOS Institute of Life Science, Aix-en-Provence, France
Protective and cleansing effect of a skincare product against pollen allergen accumulation in the hair follicle
Create easily your professional account
I create my accountGet access to exclusive dermatological services to increase your professionnal knowledge: +500 pathology visuals, clinical cases, expert videos
Benefit from valuable features: audio listening, materials to be shared with your patients
Stay informed about the upcoming events and webinars, latest scientific publications and product innovations