6 professionals
Interest of a dermo-cosmetic product in the management of radiodermatitis in breast cancer
Interest of a dermo-cosmetic product in the management of radiodermatitis in breast cancer
Helena Polena1, Arnaud Fontbonne1,2, Nathalie Ardiet1, Marlène Chavagnac-Bonneville1,2, Christelle Graizeau, Sandra Trompezinski1,2 and Michèle Sayag1
1NAOS Group, Research and Development Department, Lyon, France
2NAOS Institute of Life Science, Aix-en-Provence, France
Related topics
Acute or chronic radiodermatitis are the most common skin reaction induced by radiotherapy. The acute lesions are the most frequent and appear 2 to 3 weeks after treatment initiation, resulting in a heavy burden for concerned patients.
To evaluate the skin barrier function and the interest of a dermo-cosmetic product in the management of radiodermatitis in breast cancer.
First, the total lipids (cholesterol, free fatty acids, ceramides) and the transepidermal water loss (TEWL) were measured at D0 and D28 on 20 and 10 healthy subjects, after twice daily application of the product. Second, 45 breast cancer patients presenting grade 1 radiodermatitis according to the CTCAE version 5.0 were included in a prospective multicentric observational study. The efficacy, safety and quality of life were assessed after at least 4 weeks (2 weeks during and after radiotherapy) of product application once to twice daily.
The quantity of total lipids increased significantly by +21%, and the TEWL decreased significantly by -11.8% after 4 weeks of product application. In the clinical study, erythema (-90%), dryness (-100%), and desquamation (-100%) decreased significantly and the lesions disappeared in 93.3% of the subjects. The product was deemed good to very good as a supportive care in radiotherapy by the investigators. The intensity of burning sensation decreased significantly by -73.5%, and pain or itching were not relevant. 82.2% to 93.3% of the subjects agreed that the product nourishes and restores the skin, reduces discomfort and protects the skin from radiotherapy. The product was very well tolerated by all subjects and no negative effect was observed on subject’s quality of life.
Topical application of a specific dermo-cosmetic product, with an appropriate protocol, maintain skin hydration and integrity, making this exhausting process less traumatic to patients, and easier to complete.
Helena Polena1, Arnaud Fontbonne1,2, Nathalie Ardiet1, Marlène Chavagnac-Bonneville1,2, Christelle Graizeau, Sandra Trompezinski1,2 and Michèle Sayag1
1NAOS Group, Research and Development Department, Lyon, France
2NAOS Institute of Life Science, Aix-en-Provence, France
Polena H.1, Fontbonne A.1,2, Ardiet N.1, Chavagnac-Bonneville M.1,2, Trompezinski S1,2, and Sayag M.1
1NAOS Group, Research and Development Department, Aix-en-Provence, France
2NAOS Institute of Life Science, Aix-en-Provence, France
Create easily your professional account
I create my accountGet access to exclusive dermatological services to increase your professionnal knowledge: +500 pathology visuals, clinical cases, expert videos
Benefit from valuable features: audio listening, materials to be shared with your patients
Stay informed about the upcoming events and webinars, latest scientific publications and product innovations