> CLINICAL RESULTS
GENERALITIES
Cicabio Crème increases the level of skin hydration by 24.3% in 4 days. Cicabio crème has significant insulating power compared with the untreated area* (1)
In a model of superficial abrasion, the application of Cicabio Crème for 8 days allowed a gradual skin repair (measuring the Transepidermal Water Loss) (2)
ACTION ON NON-WEEPING SKIN LESIONS
After 14 days of Cicabio Crème application twice daily, the result showed a significant decrease in: (3)
- Erythema (-71%) **
- Oedema (-93%) **
- Pain (-92%) **
- Pruritus (-82%) **
After 14 days, for 94% of patients, the skin damage disappeared or became very slight. (3)
ACTION ON POST-PEELING & POST-LASER SKINS
After 7 days, the application of Cicabio Crème in 504 patients after a peeling or laser procedure twice daily, we observed a significant decrease in: (4)
Oedema intensity (-91%) **
- Pain (-96%) ***
- Burning (-85%) ***
- Erythema (-81%) ***
- Itching (-85%) **
In this same clinal study, we observed a disappearance or only slight remaining skin damage in 94% of patients who presented with mild, moderate, or significant skin damage at D0. This progression was highly significant for patients whose skin damage at D0 was moderate or significant****(4)
Dermatologists also evaluated the re-epidermisation state: the re-epidermisation was considered good to excellent in 98% of cases, after 7 days. (4)
Another clinical study shows that after 7 days and still after 28 days, Cicabio Crème significantly reduces pigmentation on the laser treated site versus control group (use a basic cream)*. The results also show that Cicabio Crème help to accelerate the oedema resumption on D3 (vs control group) *(5)
ACTION ON SKIN TREATED BY PHOTOTHERAPY
The soothing and repairing cream is applied to the lesions treated by dynamic phototherapy (DP), at the end of the session, then twice a day for 15 days. A series of 3 sessions is performed every 15 days. (6)
Skin condition assessment indicates:
- A decrease in the erythema intensity (-61%)* 15 days after the 1st DP session and disappearance of the edema for all subjects (6)
- Quality of skin repair judged as good to excellent in 88% of cases, after 15 days. (6)
Evaluation of subjective signs indicates:
Immediately after the PDT sessions, the application of the cream resulted in a significant decrease in (6):
- pain intensity (-49%) *****
- tightness (-60%) *****
- burning sensation (-52%) *****
- pruritus (-42%) *****
TOLERANCE
Cicabio Crème demonstrates very good skin tolerance (7)
For phototherapy patients, the tolerance was evaluated very good after the DP sessions. (6)
*p<0,005, Wilcoxon test **p<0,001, Wilcoxon test ***p<0,0001, Wilcoxon test ****p<0,00001, Wilcoxon test *****p<0,005 Student test
> PATIENTS FEEDBACKS
90% of patients found their skin more comfortable, 90% suppler and 98% softer (7)
95% of patients that tested Cicabio Crème would use it in case of lesion or irritation (7)
100% of patients found Cicabio Crème easy to spread (8)
(1) Usage test on 20 volunteers aged 22 to 67, with dry to very dry and sensitive skin, for 7 days.
(2) TEWL test on 29 volunteers, for 35 days.
