Sébium Sensitive

• Moisturizes the skin up to 24h after application (+23,1%) *⁽¹⁾
• Soothes the skin: reduction in cutaneous reactivity (-42%)** and redness ^(2,3)
• Decreases imperfections and sebum production (-32%**) ^(3,4,5)
• Inflastop^TM complex targets the biological mechanisms responsible for inflammatory phenomena, to soothe irritation, reduce redness, resorb inflamed pimples and limit their growth.
• Makes it easier for 88% of patients to follow their treatment ⁽⁶⁾

Very good cutaneous and ocular tolerance ⁽⁷⁾ – Non sticky – Non greasy – Non shiny - Mattifying ⁽⁸⁾ - non comedogenic ⁽⁸⁾

Clinically tested on patients under dermatological treatment for moderate or severe acne

* p=0.059, Student’s t-test, after 24 hours / **p<0.001, Student's test, after 28 days

(1) Evaluation of hydration level of Sébium Sensitive by corneometry -10 patients (aged 35 -65 years old) with dry or dehydrated skin with only one application. France. 2016
(2) Evaluation of soothing effect of Sébium Sensitive - 20 patients (aged 19 - 39 years old) with dry or dehydrated skin. France. 2016
(3) Evaluation of the sebo-regulating and skin barrier reconstructing power of Sébium Sensitive – 24 patients (aged 21 – 40 years old) with acne-prone skin and oily facial skin. Bulgaria. 2016
(4) Evaluation and tolerance assessment of Sébium Sensitive, non-comparative study, observational, monocentric – 33 patients (aged 14 – 31 years old) with patients treated for their moderate to severe acne. Poland. 2016
(5) Evaluation and tolerance assessment of Sébium Sensitive, non-comparative study, observational, multi-center – 33 patients (aged 14 – 33 years old) with severe facial acne under anti-acne medical treatment. Germany. 2020
(6) Clinical trial – 56 days of use of Sebium Sensitive – 32 patients. Germany.2018
(7) User test on Sébium Sensitive – 18 volunteers (aged 19 - 40 years old) with oily skin, acne-prone or sensitive of fragile skin. France. 2016
(8) Non comedogenicity of Sébium Sensitive – 23 patients (aged 24 – 62 years old) with combination to oily acne-prone skin. France. 2015

> CLINICAL RESULTS

GENERALITIES
Sebium Sensitive increases significantly the hydration level of the skin until 24h after application (+23,1%) ** it is considered as a very good moisturizer.⁽¹⁾

After 28 days of use, Sebium sensitive significantly decreases:  

• cutaneous reactivity by 42%*****⁽²⁾
• erythema by 34%*****⁽²⁾
• porphyrins level by -20%*⁽³⁾ indicator of virulence of Cutibacterium Acnes involved in the formation of inflammation
• sebum production by -32%**⁽⁴⁾
• TEWL ^(a) by 20%**⁽⁴⁾ demonstrating an improvement of the skin’s barrier function.

.^(a) TEWL: Trans Epidermal Water Loss. The higher it is, the more water is retained in the skin and therefore the skin has a good barrier function

After 56 days of using Sebium Sensitive combined with a topical acne treatment for moderate to severe acne, it was observed a significant decrease of ⁽⁵⁾:

• Number of retentional lesions (-37%) ****
• Erythema (-74%) ****
• Roughness (-87%) ****
• Sensations of discomfort (-94%) ****
• Tightness sensation (-93%) ****
• Number of inflammatory lesions (-54%) ****
• Desquamation (-96%) ***
• Dryness (-94%) ****
• Prurit (-95%) ***
• Burning sensation (-96%) ****

and combined with a keratolytic treatment for moderate to severe acne, a significant decrease of ⁽⁶⁾ :

• Number of retentional lesions (-35%) ******
• Erythema (-61%) ******
• Roughness (-64%) ******
• Sensations of discomfort (-77%) ******
• Tightness sensation (-77%) ******
• Number of inflammatory lesions (-60)******
• Desquamation (-62%) ******
• Dryness (-68%) ******
• Puritus (-65%) ****** 
• Burning sensation (-78%) ******

TOLERANCE
Sébium Sensitive is very well tolerated on the ocular level and on the cutaneous level, no reaction of skin or eye signs were observed. .⁽³⁾

*p<0.05 (Student's test, after 28 days / ** p=0.059, Student’s t-test, after 24 hours
/ *** p<0.01; mixt ANOVA model, after 56 day /**** p<0.001, mixt ANOVA model, after 56 days
/*****p<0.001, Student's test, after 28 days/ ******: p<0.001, Wilcoxon test, after 56 days

> PATIENTS FEEDBACKS
For more than 80% of the patients, the skin seems to be more comfortable, and suppler. Moreover, the inflamed pimples appear less red, and skin seems clearer. ⁽³⁾

After 28 days of application, skin is less sensitive for 83% of subjects ⁽⁷⁾. For more than 88% of subjects, the product leaves the skin comfortable all day long ^(5,6).

After 56 days of application, for more than 91% of subjects, the product soothes irritations of sensitive skin due to dermatological treatment, allows them to easier follow their dermatological treatment and to bear it ⁽⁶⁾.

(1) Evaluation of hydration level of Sébium Sensitive by corneometry -10 patients (aged 35 -65 years old) with dry or dehydrated skin with only one application. France. 2016
(2) Evaluation of soothing effect of Sébium Sensitive - 20 patients (aged 19 - 39 years old) with dry or dehydrated skin. France. 2016
(3) User test on Sébium Sensitive – 18 volunteers (aged 19 - 40 years old) with oily skin, acne-prone or sensitive of fragile skin. France. 2016
(4) Evaluation of the sebo-regulating and skin barrier reconstructing power of Sébium Sensitive – 24 patients (aged 21 – 40 years old) with acne-prone skin and oily facial skin. Bulgaria. 2016
(5) Evaluation and tolerance assessment of Sébium Sensitive, non-comparative study, observational, monocentric – 33 patients (aged 14 – 31 years old) with patients treated for their moderate to severe acne. Poland. 2016
(6) Evaluation and tolerance assessment of Sébium Sensitive, non-comparative study, observational, multi-center – 33 patients (aged 14 – 33 years old) with severe facial acne under anti-acne medical treatment. Germany. 2020
(7) Non comedogenicity of Sébium Sensitive – 23 patients (aged 24 – 62 years old) with combination to oily acne-prone skin. France. 2015